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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM4 All Species: 39.09
Human Site: T778 Identified Species: 61.43
UniProt: P33991 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33991 NP_005905.2 863 96558 T778 Q S A T D P R T G I V D I S I
Chimpanzee Pan troglodytes XP_528129 863 96543 T778 Q S A T D P R T G I V D I S I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535063 929 104136 T844 Q S A T D P R T G I V D I S I
Cat Felis silvestris
Mouse Mus musculus P49717 862 96718 T777 Q S A T D P R T G I V D I S I
Rat Rattus norvegicus NP_387500 862 96552 T777 Q S A T D P R T G I V D I S I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515513 863 97108 T778 Q S A T D P R T G I V D I S I
Chicken Gallus gallus XP_424376 859 96866 T774 Q S A T D P R T G I V D I S I
Frog Xenopus laevis P30664 863 97105 T778 Q S A T D P R T G I V D I S I
Zebra Danio Brachydanio rerio NP_944595 750 84021 D671 L D M A V L K D Y I A F A R T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 S780 Q S A T D P L S G K I D V G I
Honey Bee Apis mellifera XP_624670 636 71159 D557 L T A Y V T K D P E T G Q L I
Nematode Worm Caenorhab. elegans Q21902 759 84917 N680 I E A A A T G N L A G V E G F
Sea Urchin Strong. purpuratus XP_801985 910 101460 D825 Q A A F D P R D G T I N I D I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 K637 L R L M Q M S K I S L Y A D D
Baker's Yeast Sacchar. cerevisiae P30665 933 104985 T842 D Y A T D P K T G K I D M N L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.6 N.A. 94.9 95.1 N.A. 92.4 86.3 85.7 71.3 N.A. 60.1 42.1 28.1 63.3
Protein Similarity: 100 100 N.A. 90 N.A. 97 97.3 N.A. 96.1 93.1 92.9 78.7 N.A. 77.3 54.3 46.9 76.3
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 100 6.6 N.A. 60 13.3 6.6 53.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 100 13.3 N.A. 80 26.6 6.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. 28.9 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. 46.5 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 87 14 7 0 0 0 0 7 7 0 14 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 74 0 0 20 0 0 0 67 0 14 7 % D
% Glu: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 7 % F
% Gly: 0 0 0 0 0 0 7 0 74 0 7 7 0 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 7 60 20 0 60 0 74 % I
% Lys: 0 0 0 0 0 0 20 7 0 14 0 0 0 0 0 % K
% Leu: 20 0 7 0 0 7 7 0 7 0 7 0 0 7 7 % L
% Met: 0 0 7 7 0 7 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 0 0 0 7 0 7 0 % N
% Pro: 0 0 0 0 0 74 0 0 7 0 0 0 0 0 0 % P
% Gln: 67 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % Q
% Arg: 0 7 0 0 0 0 60 0 0 0 0 0 0 7 0 % R
% Ser: 0 60 0 0 0 0 7 7 0 7 0 0 0 54 0 % S
% Thr: 0 7 0 67 0 14 0 60 0 7 7 0 0 0 7 % T
% Val: 0 0 0 0 14 0 0 0 0 0 54 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 7 0 0 0 0 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _